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    Commercial:¥1500(Polyclonal antibodies)/Unit  
    Non-commercial:¥1500(Polyclonal antibodies)/Unit  
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CZRZ Catalog ID: PA10
Product: STAT1
Abbreviation: STAT1
Isotype: IgG
Cellular Localization: Cytoplasm, nucleus
Antibody type: Rabbit Polyclonal Antibody
Genecard: STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.
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Species Reactivity: Human, mouse, rat, Zebrafish
Antibody Description: unspecified
Recommended Dilutions:: WB: 1:1,000 ICC: 1:200
Size: 100ul liquid
Phenotype:
Note:
Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84