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    CZRZ Catalog ID: CZ1254
    Availability: Embryos/Adults
    Genotype: apcihb347/+
    Affected Gene:   apc (1)
    Genotyping: unspecified
    GENOTYPE COMPOSITION
    Genomic Feature Zygosity Parental Genotype Lab of Origin Construct
    ihb347 heterozygous   Yonghua Sun Lab
    Background: AB Affectedgeneurl: unspecified Linetype: Mutant Previous Names: cb965 (1), im:7150932, im:7152872 Background: AB Affectedgeneurl: unspecified Linetype: Mutant Previous Names: cb965 (1), im:7150932, im:7152872
    Note:
    Predicted to have beta-catenin binding activity; microtubule binding activity; and protein kinase regulator activity. Involved in several processes, including animal organ development; chordate embryonic development; and embryonic pectoral fin morphogenesis. Predicted to localize to several cellular components, including the beta-catenin destruction complex; intracellular non-membrane-bounded organelle; and lateral plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including adenoma; carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway)
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